Phase I study of orally administered S-1 in combination with epirubicin and oxaliplatin in patients with advanced solid tumors and chemotherapy-naïve advanced or metastatic esophagogastric cancer.
Identifieur interne : 000110 ( Main/Exploration ); précédent : 000109; suivant : 000111Phase I study of orally administered S-1 in combination with epirubicin and oxaliplatin in patients with advanced solid tumors and chemotherapy-naïve advanced or metastatic esophagogastric cancer.
Auteurs : Markus Moehler [Allemagne] ; Rolf Mahlberg [Allemagne] ; Volker Heinemann [Allemagne] ; Radka Obermannová [République tchèque] ; Eugen Kubala [République tchèque] ; Bohuslav Melichar [République tchèque] ; Arndt Weinmann [Allemagne] ; Paul Scigalla [Allemagne] ; Marietta Tesa Ová [République tchèque] ; Petr Janda [République tchèque] ; Fabienne Hédouin-Biville [France] ; Wasat Mansoor [Royaume-Uni]Source :
- Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association [ 1436-3305 ] ; 2016.
Abstract
This phase I study investigated the safety and the maximum tolerated dose (MTD) of the oral fluoropyrimidine S-1 when combined with epirubicin and oxaliplatin (EOS).
DOI: 10.1007/s10120-016-0618-0
PubMed: 27255289
Affiliations:
- Allemagne, France, Royaume-Uni, République tchèque
- Angleterre, Bavière, Berlin, Bohême centrale, District de Haute-Bavière, Grand Manchester, Moravie, Rhénanie-Palatinat, Île-de-France
- Berlin, Brno, Manchester, Mayence, Munich, Paris, Prague
- Université Louis-et-Maximilien de Munich
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Le document en format XML
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Medizinische Klinik und Poliklinik, University Medical Center, Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany. markus.moehler@unimedizin-mainz.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>I. Medizinische Klinik und Poliklinik, University Medical Center, Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Mahlberg, Rolf" sort="Mahlberg, Rolf" uniqKey="Mahlberg R" first="Rolf" last="Mahlberg">Rolf Mahlberg</name><affiliation wicri:level="1"><nlm:affiliation>Mutterhaus Der Borromaerinnen, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mutterhaus Der Borromaerinnen, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Heinemann, Volker" sort="Heinemann, Volker" uniqKey="Heinemann V" first="Volker" last="Heinemann">Volker Heinemann</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Oncology, Klinikum Grosshadern, University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medical Oncology, Klinikum Grosshadern, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Obermannova, Radka" sort="Obermannova, Radka" uniqKey="Obermannova R" first="Radka" last="Obermannová">Radka Obermannová</name><affiliation wicri:level="3"><nlm:affiliation>Clinic of Comprehensive Cancer Care, MOU, Brno, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Clinic of Comprehensive Cancer Care, MOU, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Kubala, Eugen" sort="Kubala, Eugen" uniqKey="Kubala E" first="Eugen" last="Kubala">Eugen Kubala</name><affiliation wicri:level="1"><nlm:affiliation>Faculty Hospital Hradec Králové, Hradec Králové, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Faculty Hospital Hradec Králové, Hradec Králové</wicri:regionArea><wicri:noRegion>Hradec Králové</wicri:noRegion></affiliation></author><author><name sortKey="Melichar, Bohuslav" sort="Melichar, Bohuslav" uniqKey="Melichar B" first="Bohuslav" last="Melichar">Bohuslav Melichar</name><affiliation wicri:level="1"><nlm:affiliation>Palacky University Medical School and Teaching Hospital, Olomouc, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Palacky University Medical School and Teaching Hospital, Olomouc</wicri:regionArea><wicri:noRegion>Olomouc</wicri:noRegion></affiliation></author><author><name sortKey="Weinmann, Arndt" sort="Weinmann, Arndt" uniqKey="Weinmann A" first="Arndt" last="Weinmann">Arndt Weinmann</name><affiliation wicri:level="3"><nlm:affiliation>I. Medizinische Klinik und Poliklinik, University Medical Center, Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>I. Medizinische Klinik und Poliklinik, University Medical Center, Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Scigalla, Paul" sort="Scigalla, Paul" uniqKey="Scigalla P" first="Paul" last="Scigalla">Paul Scigalla</name><affiliation wicri:level="3"><nlm:affiliation>Pharmaceutical Research Consulting, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pharmaceutical Research Consulting, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Tesa Ova, Marietta" sort="Tesa Ova, Marietta" uniqKey="Tesa Ova M" first="Marietta" last="Tesa Ová">Marietta Tesa Ová</name><affiliation wicri:level="3"><nlm:affiliation>Prague Clinical Services, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Prague Clinical Services, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Janda, Petr" sort="Janda, Petr" uniqKey="Janda P" first="Petr" last="Janda">Petr Janda</name><affiliation wicri:level="3"><nlm:affiliation>Prague Clinical Services, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Prague Clinical Services, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Hedouin Biville, Fabienne" sort="Hedouin Biville, Fabienne" uniqKey="Hedouin Biville F" first="Fabienne" last="Hédouin-Biville">Fabienne Hédouin-Biville</name><affiliation wicri:level="3"><nlm:affiliation>Nordic Group, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nordic Group, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mansoor, Wasat" sort="Mansoor, Wasat" uniqKey="Mansoor W" first="Wasat" last="Mansoor">Wasat Mansoor</name><affiliation wicri:level="3"><nlm:affiliation>The Christie Hospital NHS Foundation Trust, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Christie Hospital NHS Foundation Trust, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author></analytic><series><title level="j">Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</title><idno type="eISSN">1436-3305</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This phase I study investigated the safety and the maximum tolerated dose (MTD) of the oral fluoropyrimidine S-1 when combined with epirubicin and oxaliplatin (EOS).</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Royaume-Uni</li><li>République tchèque</li></country><region><li>Angleterre</li><li>Bavière</li><li>Berlin</li><li>Bohême centrale</li><li>District de Haute-Bavière</li><li>Grand Manchester</li><li>Moravie</li><li>Rhénanie-Palatinat</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Brno</li><li>Manchester</li><li>Mayence</li><li>Munich</li><li>Paris</li><li>Prague</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Moehler, Markus" sort="Moehler, Markus" uniqKey="Moehler M" first="Markus" last="Moehler">Markus Moehler</name></region><name sortKey="Heinemann, Volker" sort="Heinemann, Volker" uniqKey="Heinemann V" first="Volker" last="Heinemann">Volker Heinemann</name><name sortKey="Mahlberg, Rolf" sort="Mahlberg, Rolf" uniqKey="Mahlberg R" first="Rolf" last="Mahlberg">Rolf Mahlberg</name><name sortKey="Scigalla, Paul" sort="Scigalla, Paul" uniqKey="Scigalla P" first="Paul" last="Scigalla">Paul Scigalla</name><name sortKey="Weinmann, Arndt" sort="Weinmann, Arndt" uniqKey="Weinmann A" first="Arndt" last="Weinmann">Arndt Weinmann</name></country><country name="République tchèque"><region name="Moravie"><name sortKey="Obermannova, Radka" sort="Obermannova, Radka" uniqKey="Obermannova R" first="Radka" last="Obermannová">Radka Obermannová</name></region><name sortKey="Janda, Petr" sort="Janda, Petr" uniqKey="Janda P" first="Petr" last="Janda">Petr Janda</name><name sortKey="Kubala, Eugen" sort="Kubala, Eugen" uniqKey="Kubala E" first="Eugen" last="Kubala">Eugen Kubala</name><name sortKey="Melichar, Bohuslav" sort="Melichar, Bohuslav" uniqKey="Melichar B" first="Bohuslav" last="Melichar">Bohuslav Melichar</name><name sortKey="Tesa Ova, Marietta" sort="Tesa Ova, Marietta" uniqKey="Tesa Ova M" first="Marietta" last="Tesa Ová">Marietta Tesa Ová</name></country><country name="France"><region name="Île-de-France"><name sortKey="Hedouin Biville, Fabienne" sort="Hedouin Biville, Fabienne" uniqKey="Hedouin Biville F" first="Fabienne" last="Hédouin-Biville">Fabienne Hédouin-Biville</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mansoor, Wasat" sort="Mansoor, Wasat" uniqKey="Mansoor W" first="Wasat" last="Mansoor">Wasat Mansoor</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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